Deeks Clinical Research Group
University of California, San Francisco, San Francisco, CA
In collaboration with the SCOPE cohort, led by Dr. Steven Deeks and Dr. Jeffrey Martin, we conduct patient-oriented cohort and interventional trials. Dr. Deeks leads the DARE UM1 Martin Delaney Collaboratory as well as is on the leadership committee for the amfAR UCSF HIV Cure Institute, two large efforts to develop curative interventions for HIV disease.
Roan Lab
University of California San Francisco/Gladstone Institute of Virology and Immunology, San Francisco, CA
In collaboration with the Roan Lab, we are investigating the immunologic signatures associated with HIV+ long-term non-progressors by performing high dimensional mass cytometry (CyTOF) from lymph node aspirate samples.
Ioannidis Lab
University of California, Berkeley, Berkeley, CA
In collaboration with Nilah Monnier Ioannidis and Ryan Chung, we are conducting whole genome-wide sequencing to investigate HIV cardiovascular risk associated with the NLRP3 pathway and identify potential novel mechanisms by which individuals have high interleukin-1β levels after ART initiation. Dr. Nilah Monnier Ioannidis is an Assistant Professor in the Electrical Engineering & Computer Sciences (Computational Biology) Department and Center for Computational Biology (CCB), and Ryan Chung is a recently graudated PhD student at the CCB. At the Ioannidis Lab, they are currently applying machine-learning and biocomputational methods for interpreting genetic variation with transcriptome variation to understand clinical relationships and predict disease risks.
Ribeiro Lab
Emory University, Atlanta, GA
In collaboration with Susan Pereira Ribeiro and Felipe Ten Caten, we are investigating the effect of metamphetamine use on inflammation and HIV transcription in ART-suppressed participants. Dr. Susan Pereira Ribeiro is an Assistant Professor and Dr. Felipe Ten Caten is a Postdoctoral Fellow with the Pathology Advanced Translational Research Unit (PATRU) in the Department of Pathology & Laboratory Medicine at Emory.
Chaturvedi Lab
University of California, Riverside, Riverside, CA
In collaboration with the Chaturvedi Lab, we will be performing CRISPR experiments to validate genes identified to be associated with inflammation and HIV transcription in ART-suppressed individuals who use methamphetamine.
Sekaly Lab
Emory University, Atlanta, GA
In collaboration with Rafick Sekaly and Jeffrey Tomalka, we are investigating the immunologic signatures associated with HIV+ individuals by performing high throughput transcriptomics analyses in individuals with unique HIV+ phenotypes. Dr. Rafick Sekaly is Co-Director of the Proteomics and Systems Biology Core at Emory University and has over 30 years of experience in immunologic research identifying the molecular mechanisms regulating the human immune response.
Yukl Lab
University of California, San Francisco, San Francisco, CA
In collaboration with the Yukl Lab, we are investigating characteristics of the HIV reservoir decay in PWH, including those who are chronic-treated, acute-treated, and elite controllers. Dr. Steven Yukl is an Associate Professor of Medicine at the University of California, San Francisco and a staff physician at the San Francisco Veterans Affairs Medical Center. His research focuses on the mechanisms that allow HIV to persist despite immune defenses and current antiviral therapies.
Abdel-Mohsen Lab
Northwestern University, Evanston, IL
In collaboration with the Abdel-Mohsen Lab, we are investigating the glycomic and metabolomic signature of HIV-susceptible cells in HIV+ long-term non-progressors. Dr. Mohamed Abdel-Mohsen is an Associate Professor of Medicine at Northwestern University.
Wang Lab
University of California, Berkeley, Berkeley, CA
In collaboration with Jingshen Wang, Lei Shi, and Junzhe Shao, we are analyzing longitudinal cytokine data and reservoir measurements associated with our acute HIV+ cohort. Dr. Jingshen Wang is an Assistant Professor in Biostatistics at the School of Public Health at Berkeley and is currently applying machine-learning methods to genetic datasets to assess the efficacy of lifestyle interventions. Lei Shi and Junzhe Shao are PhD students in Biostatistics at the School of Public Health at Berkeley and are currently working on high-dimensional statistics, causal inference, and learning theory.
Hladik Lab
University of Washington, Seattle, WA
In collaboration with Florian Hladik, German Gornalusse, and Phuong “Luna” N Vo, we are evaluating host genomic and transcriptomic predictors of the HIV reservoir. Dr. Florian Hladik is a Research Professor at the Obstetrics and Gynecology Department and Division Chief of the Clinical Research Division, Dr. German Gornalusse is a Research Assistant Professor at the Obstetrics and Gynecology Department, and Luna Vo is a Research Assistant at the Hladik Lab. At their lab, they apply genomics and mucosal immunology to study the pathogenesis of HIV and identify novel strategies for HIV cure.
Bar Lab
University of Pennsylvania, Philadelphia, Pennsylvania
In collaboration with the Bar Lab, we are investigating broadly neutralizing antibody-based interventions and autologous neutralizing antibody development in HIV+ ART-suppressed patients. Dr. Katherine Bar is an Associate Professor of Medicine at the University of Pennsylvania and the Director of the Virus and Reservoirs Core at the Penn Center for AIDS Research (Penn CFAR).
Hsue Lab
University of California, Los Angeles, Los Angeles, CA
In collaboration with the Hsue Lab, we are investigating cardiovascular co-morbidities and chronic inflammation pathways in HIV+ ART-suppressed patients. Dr. Priscilla Hsue is the Chief of the Division of Cardiology in the Department of Medicine at the University of California, Los Angeles, and is the former co-director of the UCSF Center for Excellence in Vascular Research.
Kiem and Jerome Labs
Fred Hutchinson Research Center/University of Washington, Seattle, WA
In collaboration with the Kiem and Jerome Labs, we are performing HIV sequencing into host genomes of HIV+ ART-suppressed individuals and linked to measures of HIV latency.
Hartigan-O'Connor Lab
University of California, Davis, Davis, CA
In collaboration with the Hartigan-O’Connor Lab, we performed a preclinical non-human primate study demonstrating that kansui, a botanical product, was well tolerated in rhesus macaques and resulted in increased markers of immune activation and viral transcription.
Spivak Lab
University of Utah, Salt Lake City, UT
In collaboration with the Spivak Lab and the University of Utah HIV clinical team, we are conducting a phase I randomized, placebo-controlled crossover trial to test kansui, a botanical product that has been shown to reactivate HIV ex vivo, in HIV+ ART-suppressed patients.
Kroetz Lab
University of California, San Francisco, San Francisco, CA
In collaboration with the Kroetz Lab, we are performing a genome-wide association study of host genetic predictors of CD4+ T cell recover in HIV+ Ugandans initiating ART.
